Key Benefits At A Glance:
- Reduce the risk for cardiovascular disease.
- Boost energy levels.
- Provide antioxidant protection.
- MegaNatural® BPI grape seed extract is clinically proven to lower blood pressure(2).
- Chocamine® chocolate extract is proven to lower blood pressure.
Product Description:
This year, heart disease will affect more women in Canada than any other disease. Cardiovascular afflictions can include atherosclerosis, hypertension, stroke and heart attack.
About CoQ10
Coenzyme Q10 (CoQ10) is an extremely important nutrient that every cell in your body must have in order to produce energy. It is naturally found in the energy-producing center of the cell known as the mitochondria, the part of a cell responsible for the production of energy in the form of ATP (Adenosine triphosphate). ATP serves as the cell's major energy source and drives a number of biological processes, including muscle contraction and the production of protein. CoQ10 is involved in making this important molecule.
Ubiquinone vs. Ubiquinol
Ubiquinone is the standard form of CoQ10. The body must automatically convert ubiquinone to ubiquinol - the most body-ready form of CoQ10 - to help in cell energy production by providing quick and efficient replenishment. Aging inhibits this conversion process hence the requirement for CoQ10 supplementation, where the body-ready ubiquinol form may achieve the most optimal benefits. When compared to standard CoQ10 supplements ubiquinol is: 8x better absorbed in the bloodstream; reduces exercise-induced fatigue by 90%; and slows aging by 40%(8).
Inno-Q-Nol: Kaneka QH® Ubiquinol with Q-Nol® stability
Stabilized ubiquinol from ingredient to product expiration
Ubiquinol by nature is not stable (i.e. reverts back to ubiquinone). Kaneka Corporation, the world's primary CoQ10 producer, has developed a patented process that creates the most highly stabilized form of ubiquinol as a raw ingredient - Kaneka QH® Ubiquinol. While many supplement brands utilize Kaneka QH® Ubiquinol, how it’s handled during final manufacturing has a significant impact on the stabilized form and the degree and rate to which natural destabilization will occur. To ensure the superior efficacy of ubiquinol at the time of ingestion, Innovite Health utilizes one additional manufacturing step, the patented Q-Nol® process (US Patent 6,740,338) which ensures ubiquinol in the finished product stays stable (i.e. as ubiquinol) through to product expiration.
Chocamine®
This chocolate extract contains no fat or sugar, only the key phytochemicals in cocoa, like theobromine, which support the longer-lasting, less addictive energy profile that many consumers might seek.
MegaNatural® BP
This is a patented grape seed extract made in California from a special seed blend primarily from varietal white wine grapes. The seeds are extracted with hot water, the extract is purified, concentrated and spray dried, loading natural grape phenolics into the extract, and that extract powder is used as an ingredient for dietary supplements, functional foods, and healthy beverages.
Supplement Facts:
Each softgel contains:
CoQ10 (as ubiquinol, yeast fermentation source, Kaneka QHTM)
|
..... 50mg |
Grape (Vitis vinifera) seed extract (MegaNatural®-BP, standardized to 90% total phenolics, 5% monomers)
|
..... 75mg |
Cocoa (Theobroma cacao) bean extract (ChocamineTM, standardized to12% theombromine)
|
..... 125mg |
Magnesium (Oxide, Citrate) |
..... 150mg |
Non-Medicinal Ingredients: Sunflower oil, sunflower lecithin, yellow beeswax, ascorbyl palmitate, gelatin, glycerin, curcumin, tapioca starch, natural spices/flavours (ginger, allspice, cinnamon).
Free from wheat, gluten, dairy, corn, eggs, nuts, peanuts, fish, shellfish, soy, sugar, GMO, artificial colours, flavours and preservatives.
Suggested Dose and Usage:
Adults: Take 1 softgel twice daily with meals, or as directed by a qualified healthcare practitioner.
Warnings and Contraindications:
Consult a healthcare practitioner prior to use if you are pregnant, breastfeeding or on blood pressure medications or blood thinners. Do not use if the seal is broken. Keep out of reach of children. Store in a cool dry place to preserve freshness.
References:
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Sivaprakasapillai B, et al. Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome. Metabolism. 2009 Dec;58(12):1743-6. Epub 2009 Jul 15. http://www.metabolismjournal.com/article/S0026-0495(09)00245-5/abstract
M. Robinson, et al. Effect of Grape Seed Extract on Blood Pressure in Subjects with Pre-Hypertension. J Pharm Nut Sci. 2013 :155-159. http://www.lifescienceglobal.com/home/cart?view=product&id=241
Hodgson JM, et al. Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes. Eur J Clin Nutr. 2002 Nov;56(11):1137-42. http://www.nature.com/ejcn/journal/v56/n11/full/1601464a.html
Digiesi V, et al. Coenzyme Q10 in essential hypertension. Mol Aspects Med. 1994;15 Suppl:s257-63. http://www.ncbi.nlm.nih.gov/pubmed/7752838
Langsjoen P, et al. Treatment of essential hypertension with coenzyme Q10. Mol Aspects Med. 1994;15 Suppl:S265-72. http://www.ncbi.nlm.nih.gov/pubmed/7752851
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Buitrago-Lopez A, et al. Chocolate consumption and cardiometabolic disorders: systematic review and meta-analysis. BMJ. 2011 Aug 26;343:d4488. http://www.bmj.com/content/343/bmj.d4488?view=long&pmid=21875885
Ellinger S, et al. Epicatechin ingested via cocoa products reduces blood pressure in humans: a nonlinear regression model with a Bayesian approach. Am J Clin Nutr. 2012 Jun;95(6):1365-77. Epub 2012 May 2. http://ajcn.nutrition.org/content/early/2012/05/02/ajcn.111.029330.abstract
Persson IA, et al. Effects of cocoa extract and dark chocolate on angiotensin-converting enzyme and nitric oxide in human endothelial cells and healthy volunteers--a nutrigenomics perspective. J Cardiovasc Pharmacol. 2011 Jan;57(1):44-50. http://journals.lww.com/cardiovascularpharm/pages/articleviewer.aspx?year=2011&issue=01000&article=00007&type=abstract
Desideri G, et al. Benefits in cognitive function, blood pressure, and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment: the Cocoa, Cognition, and Aging (CoCoA) study. Hypertension. 2012 Sep;60(3):794-801. Epub 2012 Aug 14. http://hyper.ahajournals.org/content/60/3/794.long
Al-Safi SA, et al. Dark chocolate and blood pressure: a novel study from Jordan. Curr Drug Deliv. 2011 Nov;8(6):595-9. http://www.eurekaselect.com/75399/article
Sudarma V, Sukmaniah S, Siregar P. Effect of dark chocolate on nitric oxide serum levels and blood pressure in prehypertension subjects. Acta Med Indones. 2011 Oct;43(4):224-8. http://www.inaactamedica.org/archives/2011/22156352.pdf
Sarriá B, et al. Hypotensive, hypoglycaemic and antioxidant effects of consuming a cocoa product in moderately hypercholesterolemic humans. Food Funct. 2012 Aug;3(8):867-74. Epub 2012 Jun 12. http://pubs.rsc.org/en/Content/ArticleLanding/2012/FO/c2fo10267f#!divAbstract
Grassi D, et al. Cocoa reduces blood pressure and insulin resistance and improves endothelium-dependent vasodilation in hypertensives. Hypertension. 2005 Aug;46(2):398-405. Epub 2005 Jul 18. http://hyper.ahajournals.org/content/46/2/398.long
Taubert D, et al. Effects of low habitual cocoa intake on blood pressure and bioactive nitric oxide: a randomized controlled trial. JAMA. 2007 Jul 4;298(1):49-60. http://jama.jamanetwork.com/article.aspx?articleid=207783
Grassi D, et al. Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate. J Nutr. 2008 Sep;138(9):1671-6. http://jn.nutrition.org/content/138/9/1671.long
Almoosawi S, et al. The effect of polyphenol-rich dark chocolate on fasting capillary whole blood glucose, total cholesterol, blood pressure and glucocorticoids in healthy overweight and obese subjects. Br J Nutr. 2010 Mar;103(6):842-50. Epub 2009 Oct 13. http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=7358604
Davison K, et al. Dose-related effects of flavanol-rich cocoa on blood pressure. J Hum Hypertens. 2010 Sep;24(9):568-76. Epub 2010 Jan 21. http://www.nature.com/jhh/journal/v24/n9/full/jhh2009105a.html
Grassi D, et al. Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons. Am J Clin Nutr. 2005 Mar;81(3):611-4. http://ajcn.nutrition.org/content/81/3/611.long
Rasic-Milutinovic Z, et al. Association of blood pressure and metabolic syndrome components with magnesium levels in drinking water in some Serbian municipalities. J Water Health. 2012 Mar;10(1):161-9. http://www.ncbi.nlm.nih.gov/pubmed/22361711
Guerrero-Romero F, Rodríguez-Morán M. The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial. J Hum Hypertens. 2009 Apr;23(4):245-51. Epub 2008 Nov 20. http://www.nature.com/jhh/journal/v23/n4/full/jhh2008129a.html
Baker WL, et al. Effect of magnesium L-lactate on blood pressure in patients with an implantable cardioverter defibrillator. Ann Pharmacother. 2009 Apr;43(4):569-76. Epub 2009 Mar 31. http://www.ncbi.nlm.nih.gov/pubmed/19336644
Lee S, et al. Effects of oral magnesium supplementation on insulin sensitivity and blood pressure in normo-magnesemic nondiabetic overweight Korean adults. Nutr Metab Cardiovasc Dis. 2009 Dec;19(11):781-8. Epub 2009 Apr 8. http://www.nmcd-journal.com/article/S0939-4753(09)00010-6/abstract
Hatzistavri LS, et al. Oral magnesium supplementation reduces ambulatory blood pressure in patients with mild hypertension. Am J Hypertens. 2009 Oct;22(10):1070-5. Epub 2009 Jul 16. http://ajh.oxfordjournals.org/content/22/10/1070.abstract
Chacko SA, et al. Magnesium supplementation, metabolic and inflammatory markers, and global genomic and proteomic profiling: a randomized, double-blind, controlled, crossover trial in overweight individuals. Am J Clin Nutr. 2011 Feb;93(2):463-73. Epub 2010 Dec 15. http://ajcn.nutrition.org/content/93/2/463
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