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<td colspan="2" width="100%"><h1>ColdNOx - AOR</h1></td>
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<td width="60%" align="left" valign="top">ColdNOx is our pick as the best cold & flu fighter available today. It combines the herb Andrographis with advanced nitric oxide technology, and reduces cold symptoms fast!</td>
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<strong>60 veg caps/box <br/>NPN # 80040811</strong>
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<h2 style="text-align: justify;">Key Benefits at a Glance:</h2>
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<li style="text-align: justify;">Reduces cold and flu symptoms quickly</li>
<li style="text-align: justify;">Reduces the frequency, severity and duration of upper respiratory tract infections</li>
<li style="text-align: justify;">Combines Andrographis with advanced <strong>N</strong>itric <strong>O</strong>xide (NO) technology to prevent infection and improve energy levels</li>
<li style="text-align: justify;">NO is an antimicrobial to help fight germs naturally</li>
<li style="text-align: justify;">Increases circulation to support recovery from illness</li>
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<h2 style="text-align: justify;">Product Description:</h2>
<p style="text-align: justify;">ColdNOx is essential during cold and flu season for those who have a weakened immune system and are prone to falling ill. ColdNOx contains Andrographis paniculata extract in combination with a supplemental source of nitric oxide (NO), potassium nitrate. This formula is the <strong>World's First</strong> Andrographis paniculata enhanced with a natural source of supplemental nitric oxide. This novel formula reduces the frequency, severity and duration of upper respiratory tract infections. NO acts as a natural antimicrobial and increases circulation to support recovery. Green tea extract and citric acid are also included in AOR’s proprietary NOx3,2,1 Technology blend as synergistic agents to improve the body’s conversion of nitrate to nitric oxide and to enhance its effectiveness.</p>
<p style="text-align: justify;">ColdNOx is our pick as the best cold & flu fighter available today. It combines Andrographis, an immune-boosting herb with advanced nitric oxide technology. NO provides the same health benefits as eating several large servings of dark leafy greens in one small capsule and is proven to prevent infection, protect the stomach, improve energy levels and exercise performance, and prevent vascular disease. When combined together, Andrographis & NO help you naturally fight germs and relieve cold symptoms fast! </p>
<h3 style="text-align: justify;">Background Information:</h3>
<p style="text-align: justify;">Andrographis paniculata is a plant found primarily in Asia and India. In Traditional Chinese Medicine, it is used to remove heat, counteract toxicity and reduce swelling. In Ayurvedic and Thai medicine, it is used to treat fever associated with infectious diseases, and Scandinavians have used it as a cold and flu remedy.</p>
<h3 style="text-align: justify;">Upper Respiratory Tract Infections, Pharyngotonsillitis, Cold and Flu</h3>
<p style="text-align: justify;">Andrographis has been shown to reduce the frequency of upper respiratory tract infections (URTIs) as well as the duration and severity of URTI symptoms of the common cold and sinusitis, bronchitis, pharyngotonsillitis and pneumonia in just 2-4 days. Such symptoms include tiredness, sleeplessness, sore throat, nasal secretions, earaches, phlegm, coughing and headaches. There is also preliminary evidence of a preventive effect. Adverse events were mild and infrequent. Collectively, the data from seven double-blind controlled trials suggest that A. paniculata is superior to a placebo in alleviating the subjective symptoms of uncomplicated URTIs.</p>
<h3 style="text-align: justify;">What Is Nitric Oxide?</h3>
<p style="text-align: justify;">Nitric oxide is an essential molecule that has a wide range of beneficial effects throughout the body. Its primary role is to facilitate communication between the body’s cells. It’s known as a powerful effector molecule and functions as an EDRF (endothelium-derived relaxation factor). Green leafy vegetables contain very high levels of nitrates, for example, celery, spinach and beetroot contain over 250mg of nitrate per 100g serving. Diets rich in fruits and vegetables such as the DASH, Mediterranean and Japanese, are associated with good health and protect against disease due to their high levels of nitrates.</p>
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<h3 style="text-align: justify;">Research:</h3>
<p style="text-align: justify;">In a study of uncomplicated respiratory disease in 39 children between the ages of 4 and 11 years, A. paniculata significantly decreased the amount of nasal secretion and nasal congestion. It also accelerated the recovery time, whereas another herbal preparation containing Echinacea extract did not show the same efficacy. The treatment was well tolerated and the use of standard medication was significantly less in the group using Andrographis versus the groups using the other herbal brand or any other standard medication.</p>
<p style="text-align: justify;">In another study in 107 school children, a randomized, placebo controlled, double-blind investigation evaluated a standardized extract of A. paniculata in the prophylaxis of the common cold during the winter season. The children received either 200 mg of the extract or a placebo daily for 3 months and were evaluated each week by a physician. During the first two months of treatment, there was no difference between the two groups. However, in the third month of treatment, there was significant difference in the occurrence of the common cold in the treated group (30%) when compared to the placebo group (62%).</p>
<p style="text-align: justify;">A study of a treatment group consisting of 95 individuals involved taking an herbal preparation containing A. paniculata for 5 days. The results of this study also showed that A. paniculata has a positive effect in the treatment of acute URTIs and helps relieve the inflammatory symptoms of sinusitis.</p>
<p style="text-align: justify;">One hundred and fifty-two adult patients with pharyngotonsillitis were enrolled in a randomized double blind study to assess the efficacy of Andrographis paniculata. The patients were randomized to receive either paracetamol or 3g/day of Andrographis paniculata or 6g/day of Andrographis paniculata for 7 days. The efficacy of paracetamol or high dose Andrographis paniculata was significantly more than that of low dose Andrographis paniculata at day 3 in terms of the relief of fever and sore throat. The clinical effects were not different at day 7.</p>
<h3 style="text-align: justify;">Inhibiting Pathogens</h3>
<p style="text-align: justify;">Andrographis is thought to inhibit the growth of certain pathogens and inhibit access to cells by microbes and the toxins they produce. Studies have also found that Andrographis can reduce the symptoms and severity of colon issues such as acute diarrhea, bacillary dysentery (bacterial infection of the gut mucosa with blood in the stool) and urinary tract infections.</p>
<p style="text-align: justify;">Most people turn to antibiotics for eliminating infections. However, alternatives such as Andrographis paniculata are beneficial for both bacterial and viral infections.</p>
<h2 style="text-align: justify;">Supplement Facts:</h2>
<p style="text-align: justify;">Serving Size: 1 Capsule</p>
<p style="text-align: justify;">Andrographis paniculata extract (33% andrographolides) ..... 300 mg</p>
<p style="text-align: justify;"><strong>Non-Medicinal Ingredients</strong>: potassium nitrate (providing 259 mg nitrate), green tea extract, citric acid, microcrystalline cellulose, sodium stearyl fumarate, silicon dioxide.Capsule: hypromellose.</p>
<p style="text-align: justify;"><strong>AOR Guarantees:</strong> that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, peanuts, sesame seeds, sulphites, mustard, dairy, soy, eggs, fish, shellfish or any animal byproduct.</p>
<h2 style="text-align: justify;">Suggested Dose and Usage:</h2>
<p style="text-align: justify;">Take 1 capsule twice daily, or as directed by a qualified health care practitioner.</p>
<h2 style="text-align: justify;">Warnings And Contraindications:</h2>
<p style="text-align: justify;">Consult a health care practitioner prior to use if you are taking immunosuppressant, anticoagulant, antiplatelet, hypotensive, erectile dysfunction or nitrate-containing medications (or supplements). Do not use if you are allergic to plants of the Acanthaceae family. Some people may experience gastric discomfort, vomiting and/or loss of appetite. Consult a health care practitioner if symptoms persist or worsen or for use beyond 7 days. Keep out of reach of children.</p>
<p style="text-align: justify;">Pregnancy/Nursing: Do not use.</p>
<h2 style="text-align: justify;">Additional Learning And Information:</h2>
<ol>
<li style="text-align: justify;"><strong><a target="_blank" title="Power of Nitric Oxide" href="http://cloud.zwell.ca/images/stories/AORAdditionalInfo/The-Power-of-Nitric-Oxide-Say-Yes-To-NO.pdf">The Power of Nitric Oxide - Say Yes to NO</a></strong> (from AOR)</li>
<li style="text-align: justify;"><strong><a target="_blank" href="http://cloud.zwell.ca/images/stories/AORAdditionalInfo/The-Immune-System_Hard-At-Work-To-Keep-You-Healthy.pdf">The Immune System - Hard At Work To Keep You Healthy</a></strong> (from AOR)</li>
</ol>
<p style="text-align: justify;"><span style="font-size: 8pt;"> </span></p>
<p style="text-align: justify;"><span style="font-size: 8pt;">Statements about these products and health conditions have not been evaluated by Health Canada or the U.S. Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent disease. For the Complete disclosure statement <a href="http://reflexir.ca/disclosure.html" target="_blank">click here</a>.</span></p>
<p style="text-align: justify;"><strong>References:</strong><br/>1. The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nitric Oxide. 2010 Feb 15;22(2):104-9. Lundberg JO, Weitzberg E, Gladwin MT.<br/>2. Dietary nitrate–good or bad? Nitric Oxide. 2010 Feb 15;22(2):104-9. Gilchrist M, Winyard PG, Benjamin N.<br/>3. Food sources of nitrates and nitrites: the physiologic context for potential health benefits. Am J Clin Nutr. 2009 Jul;90(1):1-10. Hord NG, Tang Y, Bryan NS.<br/>4. Vascular system: role of nitric oxide in cardiovascular diseases. J Clin Hypertens (Greenwich). 2008 Apr;10(4):304-10. Bian K, Doursout MF, Murad F.<br/>5. Dietary polyphenols generate nitric oxide from nitrite in the stomach and induce smooth muscle relaxation. Toxicology. 2009 Nov 9;265(1-2):41-8. Rocha BS, Gago B, Barbosa RM, Laranjinha J.<br/>6. Apples increase nitric oxide production by human saliva at the acidic pH of the stomach: a new biological function for polyphenols with a catechol group? Free Radic Biol Med. 2005 Sep 1;39(5):668-81. Peri L, Pietraforte D, Scorza G, Napolitano A, Fogliano V, Minetti M.<br/>7. The inhibition of bacterially mediated N-nitrosation by vitamin C: relevance to the inhibition of endogenous N-nitrosation in the achlorhydric stomach. Carcinogenesis. 1989 Feb;10(2):397-9.<br/>Mackerness CW, Leach SA, Thompson MH, Hill MJ. <br/>8. Tea polyphenols: prevention of cancer and optimizing health. Am J Clin Nutr. 2000 Jun; 71(6 Suppl): 1698S-702S; discussion 1703S-4S. Mukhtar H, Ahmad N.</p>
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